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KMID : 0351619710120010079
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Kyungpook Medical Journal
1971 Volume.12 No. 1 p.79 ~ p.82
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The Effect of Carbon Tetrachloride on the Amino Acid Metabolism of Liver in Rats
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Abstract
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This study was undertaken to evaluate the effects of carbon tetrachloride on the cellular transport of alpha-aminoisobutyric acid-1´C a~zd incorporation into proteins and conversion to ´~CO~ of amino acids mixed-1~C in rats.
Administration of carbon tetrachloride by means of stomach tube in fast caused a significa:at decrease of the cellular transport together with the decrease of the incorporation into protein .in liver. The incorporation also decreased in serum protein but showed no noticeable change in kidneyprotein.
The activities of expired ´~CO~ at varied intervals following the administration of amino acids mixed-1~C were not significantly altered by carbon tetrachloride poisoning.
From the experimental results, it is deduced that the decreasing effect of carbon tetrachloride on liver protein synthesis is due to the decrease of amino acid transport as well as the toxic effects on protein synthetic sites.
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